Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo
ZZ Wang, P Au, T Chen, Y Shao, LM Daheron… - Nature …, 2007 - nature.com
Nature biotechnology, 2007•nature.com
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells
using a scalable two-dimensional method that avoids an embryoid-body intermediate. After
transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells
contributed to arborized blood vessels that integrated into the host circulatory system and
served as blood conduits for 150 d.
using a scalable two-dimensional method that avoids an embryoid-body intermediate. After
transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells
contributed to arborized blood vessels that integrated into the host circulatory system and
served as blood conduits for 150 d.
Abstract
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.
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