[HTML][HTML] Identification of the heparan sulfate binding sites in the cellular prion protein
RG Warner, C Hundt, S Weiss, JE Turnbull - Journal of Biological Chemistry, 2002 - ASBMB
Data from cell culture and animal models of prion disease support the separate involvement
of both heparan sulfate proteoglycans and copper (II) ions in prion (PrP) metabolism.
Though direct interactions between prion protein and heparin have been recorded, little is
known of the structural features implicit in this interaction or of the involvement of copper (II)
ions. Using biosensor and enzyme-linked immunosorbent assay methodology we report
direct heparin and heparan sulfate-binding activity in recombinant cellular prion protein (PrP …
of both heparan sulfate proteoglycans and copper (II) ions in prion (PrP) metabolism.
Though direct interactions between prion protein and heparin have been recorded, little is
known of the structural features implicit in this interaction or of the involvement of copper (II)
ions. Using biosensor and enzyme-linked immunosorbent assay methodology we report
direct heparin and heparan sulfate-binding activity in recombinant cellular prion protein (PrP …