Neurotrophins comprise a group of neuronal growth factors that are essential for the
development and maintenance of the nervous system. However, the immature pro-
neurotrophins promote apoptosis by engaging in a complex with sortilin and the p75
neurotrophin receptor (p75 NTR). To identify the interaction site between sortilin and p75
NTR, we analyzed binding between chimeric receptor constructs and truncated p75 NTR
variants by co-immunoprecipitation experiments, surface plasmon resonance analysis, and …