[HTML][HTML] JAK2, Ras, and Raf Are Required for Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase by Growth Hormone (∗)
LA Winston, T Hunter - Journal of Biological Chemistry, 1995 - ASBMB
Protein-tyrosine kinases (PTKs) of the JAK family have been characterized on the basis of
their ability to mediate the rapid induction of transcription of interferon-responsive genes
through the stimulation of a class of latent cytoplasmic transcription factors known as signal
transducers and activators of transcription (STATs). STAT activation, which has been
described as being Ras-independent, requires tyrosine phosphorylation, but STAT
transactivating activity is enhanced by phosphorylation on serine as well, probably by …
their ability to mediate the rapid induction of transcription of interferon-responsive genes
through the stimulation of a class of latent cytoplasmic transcription factors known as signal
transducers and activators of transcription (STATs). STAT activation, which has been
described as being Ras-independent, requires tyrosine phosphorylation, but STAT
transactivating activity is enhanced by phosphorylation on serine as well, probably by …