Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the …
C Buerger, K Nagel-Wolfrum, C Kunz, I Wittig… - Journal of biological …, 2003 - ASBMB
Receptor tyrosine kinases of the epidermal growth factor (EGF) receptor family regulate
essential cellular functions such as proliferation, survival, migration, and differentiation but
also play central roles in the etiology and progression of tumors. We have identified short
peptide sequences from a random peptide library integrated into the thioredoxin scaffold
protein, which specifically bind to the intracellular domain of the EGF receptor (EGFR).
These molecules have the potential to selectively inhibit specific aspects of EGF receptor …
essential cellular functions such as proliferation, survival, migration, and differentiation but
also play central roles in the etiology and progression of tumors. We have identified short
peptide sequences from a random peptide library integrated into the thioredoxin scaffold
protein, which specifically bind to the intracellular domain of the EGF receptor (EGFR).
These molecules have the potential to selectively inhibit specific aspects of EGF receptor …
