Gene silencing in cancer in association with promoter hypermethylation
This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key
event in the development of cancer. The silencing can be effected by a disabling mutation or
by a shutting down of the promoter region, the site at which transcription of the gene begins.
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key
event in the development of cancer. The silencing can be effected by a disabling mutation or
by a shutting down of the promoter region, the site at which transcription of the gene begins.
This article reviews the mechanisms of gene silencing in cancer and clinical applications of this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key event in the development of cancer. The silencing can be effected by a disabling mutation or by a shutting down of the promoter region, the site at which transcription of the gene begins.
The New England Journal Of Medicine