Chemokine mediated neuron–glia communication and aberrant signalling in neuropathic pain states
EA Old, M Malcangio - Current opinion in pharmacology, 2012 - Elsevier
Treatment of neuropathic pain is problematic; response to current pharmacological
interventions is often poor and associated with undesirable side-effects, thus the
identification of new targets for treating this condition is needed. Here we collect evidence
demonstrating the potential of chemokines as mediators of neuron–glia communication and
contributors to pain signalling. The expression of chemokines such as CX3CL1, CCL2 and
CCL21 and their receptors CX3CR1, CCR2 and CXCR3 is altered in the spinal cord under …
interventions is often poor and associated with undesirable side-effects, thus the
identification of new targets for treating this condition is needed. Here we collect evidence
demonstrating the potential of chemokines as mediators of neuron–glia communication and
contributors to pain signalling. The expression of chemokines such as CX3CL1, CCL2 and
CCL21 and their receptors CX3CR1, CCR2 and CXCR3 is altered in the spinal cord under …