Changes in circulating carcinoma cells in patients with metastatic prostate cancer correlate with disease status
JG Moreno, SM O'Hara, S Gross, G Doyle, H Fritsche… - Urology, 2001 - Elsevier
Objectives. To investigate the diurnal variations in circulating tumor cells (CTCs) in
metastatic carcinoma of the prostate (CAP) and to determine whether the change in CTCs
correlated with disease progression. Methods. Samples were prepared by immunomagnetic
selection of cells from 7 mL of blood targeting the epithelial cell adhesion molecule and
differential fluorescent labeling of the collected cells using a nucleic acid dye, antibodies
directed against the common leukocyte (CD45), and cytokeratin antigens. Events that …
metastatic carcinoma of the prostate (CAP) and to determine whether the change in CTCs
correlated with disease progression. Methods. Samples were prepared by immunomagnetic
selection of cells from 7 mL of blood targeting the epithelial cell adhesion molecule and
differential fluorescent labeling of the collected cells using a nucleic acid dye, antibodies
directed against the common leukocyte (CD45), and cytokeratin antigens. Events that …