[HTML][HTML] Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin β2 innate immune pathway defective in Crohn disease
TT Wang, B Dabbas, D Laperriere, AJ Bitton… - Journal of Biological …, 2010 - ASBMB
Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator of
innate immunity in humans. Here we show that hormonal vitamin D, 1, 25-dihydroxyvitamin
D 3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1
gene and protein in primary human monocytic and epithelial cells. The vitamin D receptor
signals through distal enhancers in the NOD2 gene, whose function was validated by
chromatin immunoprecipitation and chromatin conformation capture assays. A key …
innate immunity in humans. Here we show that hormonal vitamin D, 1, 25-dihydroxyvitamin
D 3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1
gene and protein in primary human monocytic and epithelial cells. The vitamin D receptor
signals through distal enhancers in the NOD2 gene, whose function was validated by
chromatin immunoprecipitation and chromatin conformation capture assays. A key …
