[HTML][HTML] p38 MAPK and NF-κB collaborate to induce interleukin-6 gene expression and release: evidence for a cytoprotective autocrine signaling pathway in a cardiac …
R Craig, A Larkin, AM Mingo, DJ Thuerauf… - Journal of Biological …, 2000 - ASBMB
In cardiac myocytes, the stimulation of p38 MAPK by the MAPKK, MKK6, activates the
transcription factor, NF-κB, and protects cells from apoptosis. In the present study in primary
neonatal rat cardiac myocytes, constitutively active MKK6, MKK6 (Glu), bound to IκB kinase
(IKK)-β and stimulated its abilities to phosphorylate IκB and to activate NF-κB. MKK6 (Glu)
induced NF-κB-dependent interleukin (IL)-6 transcription and IL-6 release in a p38-
dependent manner. IL-6 protected myocardial cells against apoptosis. Like IL-6, TNF-α …
transcription factor, NF-κB, and protects cells from apoptosis. In the present study in primary
neonatal rat cardiac myocytes, constitutively active MKK6, MKK6 (Glu), bound to IκB kinase
(IKK)-β and stimulated its abilities to phosphorylate IκB and to activate NF-κB. MKK6 (Glu)
induced NF-κB-dependent interleukin (IL)-6 transcription and IL-6 release in a p38-
dependent manner. IL-6 protected myocardial cells against apoptosis. Like IL-6, TNF-α …
