Immunoproteasome subunits LMP2 and LMP7 downregulation in primary malignant melanoma lesions: association with lack of spontaneous regression
J Dissemond, P Goette, J Moers, A Lindeke… - Melanoma …, 2003 - journals.lww.com
Recently, expression of the immunoproteasome subunits low molecular protein (LMP) 2 or
LMP7 was shown to reduce the presentation of certain major histocompatibility complex
(MHC) class I-restricted tumour peptide epitopes in renal cell carcinoma and melanoma
cells. This may provide the tumour cells with an immune escape mechanism. To test the
relevance of this hypothesis, we have taken advantage of the fact that spontaneous
regression of human primary melanoma is thought to be the result of a successful peptide …
LMP7 was shown to reduce the presentation of certain major histocompatibility complex
(MHC) class I-restricted tumour peptide epitopes in renal cell carcinoma and melanoma
cells. This may provide the tumour cells with an immune escape mechanism. To test the
relevance of this hypothesis, we have taken advantage of the fact that spontaneous
regression of human primary melanoma is thought to be the result of a successful peptide …
