Somatic cell nuclear transfer
I Wilmut, N Beaujean, PA De Sousa, A Dinnyes… - Nature, 2002 - nature.com
I Wilmut, N Beaujean, PA De Sousa, A Dinnyes, TJ King, LA Paterson, DN Wells, LE Young
Nature, 2002•nature.comCloning by nuclear transfer from adult somatic cells is a remarkable demonstration of
developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in
chromatin structure that govern differentiation can be reversed, and the nucleus can be
made to control development to term.
developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in
chromatin structure that govern differentiation can be reversed, and the nucleus can be
made to control development to term.
Abstract
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
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