Activation of rat hepatic stellate cells leads to loss of glutathionS-transferases and their enzymatic activity against products of oxidative stress
R Whalen, DC Rockey, SL Friedman, TD Boyer - Hepatology, 1999 - journals.lww.com
Oxidative stress, mediated partly by lipid peroxidation products, may lead to increased
collagen synthesis by hepatic stellate cells (HSC). Stellate cells are protected from oxidative
stress by enzymes of detoxication such as the glutathioneS-transferases (GSTs), which form
glutathione conjugates with lipid peroxidation products (eg, 4-hydroxy-2-nonenal [HNE]). To
better understand the role of GSTs in stellate cell biology, we examined the expression and
enzymatic activity of GSTs in normal and activated (both culture-and in vivo-activated) …
collagen synthesis by hepatic stellate cells (HSC). Stellate cells are protected from oxidative
stress by enzymes of detoxication such as the glutathioneS-transferases (GSTs), which form
glutathione conjugates with lipid peroxidation products (eg, 4-hydroxy-2-nonenal [HNE]). To
better understand the role of GSTs in stellate cell biology, we examined the expression and
enzymatic activity of GSTs in normal and activated (both culture-and in vivo-activated) …
