Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric …
Cerebellar granule cells (CGCs) can express the inducible isoform of nitric oxide synthase
(iNOS) in response to inflammatory stimuli. We demonstrate that induction of iNOS in CGCs
by bacterial lipopolysaccharide and pro-inflammatory cytokines results in cell death that was
potentiated by excess l-arginine and inhibited by the selective iNOS inhibitor, 2-amino-5, 6-
dihydro-6-methyl-4H-1, 3-thiazine. The NO-mediated cell death was accompanied by
increased caspase-3-like activity, DNA fragmentation and positive terminal transferase …
(iNOS) in response to inflammatory stimuli. We demonstrate that induction of iNOS in CGCs
by bacterial lipopolysaccharide and pro-inflammatory cytokines results in cell death that was
potentiated by excess l-arginine and inhibited by the selective iNOS inhibitor, 2-amino-5, 6-
dihydro-6-methyl-4H-1, 3-thiazine. The NO-mediated cell death was accompanied by
increased caspase-3-like activity, DNA fragmentation and positive terminal transferase …
