Anthrax vaccine: increasing intervals between the first two doses enhances antibody response in humans
PR Pittman, JA Mangiafico, CA Rossi, TL Cannon… - Vaccine, 2000 - Elsevier
PR Pittman, JA Mangiafico, CA Rossi, TL Cannon, PH Gibbs, GW Parker, AM Friedlander
Vaccine, 2000•ElsevierThe influence of dosing interval on the human antibody response to anthrax vaccine
adsorbed (AVA) was evaluated in two retrospective serological studies. In both studies, the
interval between the first two doses was 2, 3 or 4 weeks. In the first study, banked sera were
selected from 89 at-risk individuals at a mean time of 13 days after the second dose of
vaccine. In the second study, banked sera were selected from 51 at-risk individuals at a
mean time of 48 days following the first dose of AVA. In both studies, the geometric mean …
adsorbed (AVA) was evaluated in two retrospective serological studies. In both studies, the
interval between the first two doses was 2, 3 or 4 weeks. In the first study, banked sera were
selected from 89 at-risk individuals at a mean time of 13 days after the second dose of
vaccine. In the second study, banked sera were selected from 51 at-risk individuals at a
mean time of 48 days following the first dose of AVA. In both studies, the geometric mean …
The influence of dosing interval on the human antibody response to anthrax vaccine adsorbed (AVA) was evaluated in two retrospective serological studies. In both studies, the interval between the first two doses was 2, 3 or 4 weeks. In the first study, banked sera were selected from 89 at-risk individuals at a mean time of 13 days after the second dose of vaccine. In the second study, banked sera were selected from 51 at-risk individuals at a mean time of 48 days following the first dose of AVA. In both studies, the geometric mean anti-protective antigen IgG antibody titer increased significantly as the interval between the two doses increased from 2 to 4 weeks (p=0.0005–0.029). In the first study, the seroconversion rate also increased as the interval between the first two doses increased (p=0.0034). A prospective, randomized study has been completed and is being analyzed to confirm these findings.
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