Focusing on the glomerular slit diaphragm: podocin enters the picture
JH Miner - The American journal of pathology, 2002 - ASIP
The nature of the glomerular filtration barrier is currently one of the most intensely studied
and exciting problems in nephrology research, primarily because of the relatively recent
discoveries that two novel and two previously known genes are intimately involved in
glomerular filtration. The two novel genes, NPHS1 and NPHS2 (encoding nephrin and
podocin, respectively) were identified by positional cloning. NPHS1 is mutated in congenital
nephrotic syndrome of the Finnish type, 1 and NPHS2 is mutated in steroid resistant …
and exciting problems in nephrology research, primarily because of the relatively recent
discoveries that two novel and two previously known genes are intimately involved in
glomerular filtration. The two novel genes, NPHS1 and NPHS2 (encoding nephrin and
podocin, respectively) were identified by positional cloning. NPHS1 is mutated in congenital
nephrotic syndrome of the Finnish type, 1 and NPHS2 is mutated in steroid resistant …
